Optimization of Near-Infrared Fluorescent Sentinel Lymph Node Mapping for Vulvar Cancer
Identifieur interne : 004C82 ( Main/Exploration ); précédent : 004C81; suivant : 004C83Optimization of Near-Infrared Fluorescent Sentinel Lymph Node Mapping for Vulvar Cancer
Auteurs : Merlijn Hutteman [Pays-Bas] ; Joost R. Van Der Vorst [Pays-Bas] ; Katja N. Gaarenstroom [Pays-Bas] ; Alexander A. W. Peters [Pays-Bas] ; J. Sven D. Mieog [Pays-Bas] ; Boudewijn E. Schaafsma [Pays-Bas] ; Clemens W. G. M. Löwik [Pays-Bas] ; John V. Frangioni [États-Unis] ; Cornelis J. H. Van De Velde [Pays-Bas] ; Alexander L. Vahrmeijer [Pays-Bas]Source :
- American journal of obstetrics and gynecology [ 0002-9378 ] ; 2011.
Abstract
Near-infrared (NIR) fluorescence imaging has the potential to improve sentinel lymph node (SLN) mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin (ICG:HSA) was performed.
Nine vulvar cancer patients underwent the standard SLN procedure using 99mtechnetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750 or 1000 µM of ICG:HSA.
NIR fluorescence SLN mapping was successful in all patients. A total of 14 SLNs (average 1.6, range 1–4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 NIR fluorescent (100%).
This study demonstrates feasibility and accuracy of SLN mapping using ICG:HSA. Considering safety, cost, and pharmacy preferences, an ICG:HSA concentration of 500 µM appears optimal for SLN mapping in vulvar cancer.
Url:
DOI: 10.1016/j.ajog.2011.07.039
PubMed: 21963099
PubMed Central: 3246078
Affiliations:
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Van Der Vorst</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Gaarenstroom, Katja N" sort="Gaarenstroom, Katja N" uniqKey="Gaarenstroom K" first="Katja N." last="Gaarenstroom">Katja N. Gaarenstroom</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Gynecology and Obstetrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gynecology and Obstetrics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Peters, Alexander A W" sort="Peters, Alexander A W" uniqKey="Peters A" first="Alexander A. W." last="Peters">Alexander A. W. Peters</name><affiliation wicri:level="3"><nlm:aff id="A2">Department of Gynecology and Obstetrics, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Gynecology and Obstetrics, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Mieog, J Sven D" sort="Mieog, J Sven D" uniqKey="Mieog J" first="J. Sven D." last="Mieog">J. Sven D. Mieog</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schaafsma, Boudewijn E" sort="Schaafsma, Boudewijn E" uniqKey="Schaafsma B" first="Boudewijn E." last="Schaafsma">Boudewijn E. Schaafsma</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Lowik, Clemens W G M" sort="Lowik, Clemens W G M" uniqKey="Lowik C" first="Clemens W. G. M." last="Löwik">Clemens W. G. M. Löwik</name><affiliation wicri:level="3"><nlm:aff id="A3">Department of Endocrinology, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Endocrinology, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Frangioni, John V" sort="Frangioni, John V" uniqKey="Frangioni J" first="John V." last="Frangioni">John V. Frangioni</name><affiliation wicri:level="2"><nlm:aff id="A4">Department of Radiology, Beth Israel Deaconess Medical Center, Boston, MA 02215</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Department of Radiology, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A5">Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Massachusetts</region></placeName><wicri:cityArea>Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston</wicri:cityArea></affiliation></author><author><name sortKey="Van De Velde, Cornelis J H" sort="Van De Velde, Cornelis J H" uniqKey="Van De Velde C" first="Cornelis J. H." last="Van De Velde">Cornelis J. H. Van De Velde</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Vahrmeijer, Alexander L" sort="Vahrmeijer, Alexander L" uniqKey="Vahrmeijer A" first="Alexander L." last="Vahrmeijer">Alexander L. Vahrmeijer</name><affiliation wicri:level="3"><nlm:aff id="A1">Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Surgery, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">American journal of obstetrics and gynecology</title><idno type="ISSN">0002-9378</idno><idno type="eISSN">1097-6868</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Objectives</title><p id="P2">Near-infrared (NIR) fluorescence imaging has the potential to improve sentinel lymph node (SLN) mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin (ICG:HSA) was performed.</p></sec><sec id="S2"><title>Study Design</title><p id="P3">Nine vulvar cancer patients underwent the standard SLN procedure using <sup>99m</sup>technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750 or 1000 µM of ICG:HSA.</p></sec><sec id="S3"><title>Results</title><p id="P4">NIR fluorescence SLN mapping was successful in all patients. A total of 14 SLNs (average 1.6, range 1–4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 NIR fluorescent (100%).</p></sec><sec id="S4"><title>Conclusions</title><p id="P5">This study demonstrates feasibility and accuracy of SLN mapping using ICG:HSA. Considering safety, cost, and pharmacy preferences, an ICG:HSA concentration of 500 µM appears optimal for SLN mapping in vulvar cancer.</p></sec></div></front></TEI><affiliations><list><country><li>Pays-Bas</li><li>États-Unis</li></country><region><li>Hollande-Méridionale</li><li>Massachusetts</li></region><settlement><li>Leyde</li></settlement></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Hutteman, Merlijn" sort="Hutteman, Merlijn" uniqKey="Hutteman M" first="Merlijn" last="Hutteman">Merlijn Hutteman</name></region><name sortKey="Gaarenstroom, Katja N" sort="Gaarenstroom, Katja N" uniqKey="Gaarenstroom K" first="Katja N." last="Gaarenstroom">Katja N. Gaarenstroom</name><name sortKey="Lowik, Clemens W G M" sort="Lowik, Clemens W G M" uniqKey="Lowik C" first="Clemens W. G. M." last="Löwik">Clemens W. G. M. Löwik</name><name sortKey="Mieog, J Sven D" sort="Mieog, J Sven D" uniqKey="Mieog J" first="J. Sven D." last="Mieog">J. Sven D. Mieog</name><name sortKey="Peters, Alexander A W" sort="Peters, Alexander A W" uniqKey="Peters A" first="Alexander A. W." last="Peters">Alexander A. W. Peters</name><name sortKey="Schaafsma, Boudewijn E" sort="Schaafsma, Boudewijn E" uniqKey="Schaafsma B" first="Boudewijn E." last="Schaafsma">Boudewijn E. Schaafsma</name><name sortKey="Vahrmeijer, Alexander L" sort="Vahrmeijer, Alexander L" uniqKey="Vahrmeijer A" first="Alexander L." last="Vahrmeijer">Alexander L. Vahrmeijer</name><name sortKey="Van De Velde, Cornelis J H" sort="Van De Velde, Cornelis J H" uniqKey="Van De Velde C" first="Cornelis J. H." last="Van De Velde">Cornelis J. H. Van De Velde</name><name sortKey="Van Der Vorst, Joost R" sort="Van Der Vorst, Joost R" uniqKey="Van Der Vorst J" first="Joost R." last="Van Der Vorst">Joost R. Van Der Vorst</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Frangioni, John V" sort="Frangioni, John V" uniqKey="Frangioni J" first="John V." last="Frangioni">John V. Frangioni</name></region><name sortKey="Frangioni, John V" sort="Frangioni, John V" uniqKey="Frangioni J" first="John V." last="Frangioni">John V. Frangioni</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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